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10.1021/acs.est.3c04981 [DOI] [PMC free article] [PubMed] [Google Scholar] Jamei M, Dickinson GL, Rostami-Hodjegan A (2009) A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: a tale of `Bottom-Up’ vs`Top-Down’ recognition of covariates